| ncRNA name | p21Cip1 siRNA |
| ncRNA Category | siRNA |
| Disease name | cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | human lens epithelial cell line HLE-B3 |
| Methods | BrdU incorporation assay, FACS analysis, Western and Northern blot, siRNA transfection, immunohistochemistry |
| Expression pattern | associated |
| Functional description | The accumulation of p21Cip1 in lenses exposed to oxidative stress may play a role as a defensive mediator of oxidative damage, an indicator for senescence or aging, or an inducer for the formation of cataract. Attenuation of p21Cip1 expression using siRNA reduced the H2O2 induced G2/M arrest. |
| PubMed ID | 16179908 |
| Year | 2005 |
| Title | Induction of p21Cip1-mediated G2/M arrest in H2O2-treated lens epithelial cells. |
| Drug-related ncRNA | NO |
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